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A study in 2013 showed an increase in matrix metalloproteinases in the cornea and the lens after exposure to near infrared, an enzyme that degrades structural proteins

Compounds spanning 100-fold IC50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies

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While epimerization remains a promising approach for enzymatic detoxification of trichothecenes such as DON, its feasibility is limited due to the requirement for cofactors PQQ and NADPH

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