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Size and charge help bacteriocins to cross cell membranes and barriers and play important roles in different physiological mechanisms

Gerhardt, 2017)

(3) Before conducting randomized clinical trials, it is essential to use nanotechnology to enhance targeted drug delivery, control drug release, and increase drug solubility and bioavailability and to conduct necessary pharmacokinetic, pharmacodynamic, and toxicological studies

Particulate matter can come from degraded peptide falling out of solution, contamination introduced during reconstitution, or microbial growth

As an alternative, low temperature (warm water) treatments are also recommended provided that the detergent, the duration of the wash cycle, and the type of additive used are all carefully controlled to achieve a similarly clean and sanitized end result

doi: 10.1186/s12933-017-0624-5