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[13] The first reaction of the carnitine shuttle is a two-step process catalyzed by a family of isozymes of acyl-CoA synthetase that are found in the outer mitochondrial membrane , where they promote the activation of fatty acids by forming a thioester bond between the fatty acid carboxyl group and the thiol group of coenzyme A to yield a fatty acylCoA

K., Schrauwen-Hinderling, V

The clinical significance of L-carnitine in ameliorating insulin resistance (IR) lies in its intervention in a core pathogenic feature of MASLD: hepatic IR

Exp Pathol

Its also shown excellent anti-aging results in studies, reversal of symptoms in up to 50% of Parkinsons disease patients, reduced alcohol craving during recovery treatment, and even halting progression of Alzheimers symptoms

not approved for any therapeutic use