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4.5.3 Possible role of methionine Prolonged methionine deprivation blocks CHAC1 protein synthesis by interfering with its translation, thereby inhibiting ferroptosis

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24,28,29 ACSL4 first catalyzes the biochemical reaction of free AA/AdA to CoA to form AA/AdA-CoA derivatives and promotes their esterification into phospholipids, while LPCAT3 then catalyzes the biosynthesis of AA/AdA-CoA and membrane PE to form AA/AdAPE (Fig