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Additionally, most studies use mixtures of enzymatic hydrolysates of collagen, and the specific peptide sequences responsible for the anti-aging effects remain unclear [98]

Moreover, DPN symptoms often occur with subclinical dysfunction of nerves

2024 Nov

Biopolymer nanoparticles for nose-to-brain drug delivery: a new promising approach for the treatment of neurological diseases

The conserved lysine residue N-terminal to the active site, Cys A , helix 1 and helix 3 as well as the -sheets of the thioredoxin fold are almost perfectly superimposed

While there is evidence that cellular Ca 2+ handling is impaired in DbCM due to decreased SERCA2a expression, reduced activity of RyR or decreased LTCC expression, literally no data on mitochondrial Ca 2+ handling in DbCM have been published [117118]