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National Library of Medicine (2012)

The Effect of Hydroxytyrosol in Type II Epithelial-Mesenchymal Transition in Human Skin Wound Healing

Mammalian Cells Cell culture Human embryonic kidney (HEK) cells were cultured in DMEM medium, containing 4.5 g/L glucose, 10 % FCS and 1 % penicillin/streptomycin, and cultivated at 37 C in a humidified atmosphere containing 5% CO 2

Our quantitative RT-PCR results also show that female CBA/CaJ mice have elevated levels of Nrf2 that promotes the transcriptional induction of a number of Phase II detoxification genes, including Gsta , Gstm , and Gstp

On tolerability, both compounds produced mild-to-moderate gastrointestinal adverse events (nausea, diarrhea, constipation, vomiting), typically during dose escalation