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Enhancing fusion in pancreatic adenocarcinoma models, either via mitofusin 2 (MFN2) overexpression or DRP1 inhibition, paradoxically increased mitophagy, leading to reduced mitochondrial mass and OXPHOS capacity

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Persistent side effects beyond 2 weeks after a dose increase Transient nausea, mild constipation, and decreased appetite are expected and normal during the 1 to 2 weeks after each dose increase

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