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The potent de-lactylation activity of HDAC1-3, observed in both cellular and in vitro purified proteins, was first identified by Yruela et al., particularly regarding Kd-la [53]

T cell GSH, adjusted for CD4 T cell count and 2-microglobulin levels, also increased in the NAC-treated subjects ( P =0.04)

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McGill University, Montreal-Jewish General Hospital

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However, the distinct reaction rates of the very fast first and second thiol couplings, and the observed resistance towards further thiol exchange of the resulting adducts, prompted us to investigate the potential of these reagents to simply cross-click two different thiols, by their sequential addition in stoichiometric amount to a BYO reagent (Fig