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The Journal of biological chemistry 2000;275:1602316029

Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction

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Department of Medicine, University Medical Centre Mainz, Johannes Gutenberg University, Mainz, Germany, Mainz, Germany, (4)University of Texas Southwestern Medical Center, (5)Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, (6)Houston Research Institute, Houston, TX Background: Nonalchoholic fatty liver disease (NAFLD) and its severe form, nonalcoholic steatohepatitis (NASH), are associated with obesity, type 2 diabetes, and metabolic syndrome

Indeed, the data above show that all forms of vitamin B12 administered to patients with deficiency are catalyzed at this stage by glutathione, during which all axial Co-C or Co-O chemical bonds are broken, and the central cobalt atom of all forms receives an electron or a large part of the electron density reaching one electron during the reaction from the monoanion of glutathione