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388 Nrf2 inhibition Nrf2, frequently overexpressed in therapy-resistant cancers, represents a promising therapeutic target for ROS-mediated anticancer strategies, as demonstrated by Tamoxifen-resistant breast cancer cells that develop irradiation cross-resistance through Nrf2-driven antioxidant upregulation and a glycolytic shift, with Nrf2 inhibition restoring radiosensitivity in both cellular models and patient tumors (NCT00738777)

Vitamin B12 is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production

Comet assay for DNA damage Cells in culture were untreated (DMSO, control) or treated with R001 at the indicated concentrations for 24 h, or in the case of H 2 O 2 (400 M), cells were treated for 1 h

Cytokines affect the magnitude of inflammation or immune responses

Collectively, these findings indicate that Grx1 limits TDP-43 accumulation and thereby prevents its cytoplasmic aggregation

Brusatol, another diterpenoid compound, was able to inhibit EAC development through affecting NRF2