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In addition, DNA response elements can exert an allosteric effect on transcription regulators, so that the regulator can activate transcription in the context of one gene, but repress transcription in another gene

Physiol Rev 94(2):329354 Nishinaka Y, Masutani H, Nakamura H, Yodoi J (2001) Regulatory roles of thioredoxin in oxidative stress-induced cellular responses

However, Richner et al

Safety and efficacy of ERCP in pregnancy

Lastly, if there is a problem with detoxification, you can still get a false negative with this test if the body isn't able to eliminate the heavy metals through the urine

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