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It is mostly due to charge balancing ions (H + , Li + , Na + , and K + ions) and electron insertion/extraction processes (reduction/oxidation)

Gray matter volume as an intermediate phenotype for psychosis: Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP)

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The actual directionality of this interaction is still not clear, however the immune response to an external pathogen could provoke unblinded oxidative stress which in turn perpetuates a steady inflammatory cascade (Maes et al

This means that while the association is clear and the mechanisms are well-hypothesized, definitive answers about causation, dose-response relationships, and optimal prevention remain areas of active investigation