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It acts as a competitive inhibitor of PCFT folate transport, reducing folate entry into the brain

In vitro, GAD-ab interfere with GABA production [14, 15], while in vivo they affect the function of GABAergic neurons and interfere with GABA synthesis resulting in impaired inhibitory neurotransmission without causing structural brain changes [48,49,50,51]

Inositol-deficient food augments a behavioral effect of long-term lithium treatment mediated by inositol monophosphatase inhibition: an animal model with relevance for bipolar disorder

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In summary, a picture emerges that underlines the complex interplay of several or even multiple cytokines or isoforms thereof in the context of psoriasis and its comorbidities