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This metabolic adaptation, while crucial for mitochondrial function, also promotes ferroptosis in NSCLC cells under cysteine-limiting conditions, linking CHAC1 activity to cell death pathways

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It may be that an asparagine can function similarly in a gating capacity to the aspartate, and that association of this variant to SPCD involves a more complex mechanism beyond substrate transport alone

Knight, S.A

Makinen, N