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Pathogenesis of Tissue Deposition of Urate Crystals Into Tophi Besides tissue supersaturation with urate and the effects of decreased temperature and decreased tissue pH to promote decreased urate solubility, other factors promote the transformation of soluble urate into urate crystals deposited in tophi ( Figure 1 - 6 )

a , Representative 25 m maximum projections in the xy plane were captured in CX3CR1 gfp/+ mice 3 h after compression injury

Cerebral venous system and anatomical predisposition to high-altitude headache

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& Manautou, J

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