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10.3109/13880209.2012.720689 19 CaoG.ZhangC.ZhangY.CongX.CaiH.CaiB

4.3.2 Hypoxia GB TME features a necrotic core primarily formed due to high cell density or vaso-occlusive events leading to hypoxia, a pervasive feature in GB

The combination therapy of Abrine (IDO1 inhibitors) with anti-PD-1 antibody has a beneficial impact on decreasing HCC growth by upregulating CD4 + or CD8 + T cells, inhibiting Treg cells, and blocking the expression of IDO1 and PD-L1