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It is highly context-dependent: organs such as the heart and brain, with high metabolic demand and limited regenerative capacity, are particularly vulnerable to resilience failure, whereas cancer cells exploit enhanced proteostasis resilience to support uncontrolled proliferation and therapy resistance

PLoS ONE 10:e0134303 Mizunoya W, Okamoto S, Miyahara H et al (2017) Fast-to-slow shift of muscle fiber-type composition by dietary apple polyphenols in rats: impact of the low-dose supplementation

Shen, K

Moradi S, Khazaei M, Rashidi Z

The importance of SOD becomes evident when examining its evolutionary conservation across species, from bacteria to humans, indicating its fundamental role in protecting aerobic life from oxygen toxicity

Other methods include bisulfite genome sequencing, pyrosequencing, methylation-specific dot blot assay, among others (Gurioli et al., 2018)