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Glutathione taken at night may thus be in harmony with these natural cycles and work cooperatively with the nighttime repair cycle of the body

Put serves as the starting point of the polyamines pathway, derived either from ornithine in the cytosol [85] or from arginine in the chloroplast [86], before becoming a precursor molecule in the subsequent synthesis of Spm and Spd [87]

GAPDH Glyceraldehyde-3-phosphate dehydrogenase Sense: TGGCAAGTTCAACGGCACAGT Antisense: TTTGGCCTCACCCTTCAGGT 193 bp XM_221353 iNOS (NOS-2) Inducible nitric oxide synthase Sense: TTGGAGCGAGTTGTGGATTGTTGTTC Antisense: GGTGAGGGCTTGCCTGAGTGAGC 126 bp NM_012611 eNOS (NOS-3) Endothelial nitric oxide synthase Sense: CTGGCAAGACCGATTACACGA Antisense: TCAGGAGGTCTTGCACATAGG 206 bp NM_021838 COX-2 Cyclooxygenase-2 Sense: CTGTATCCCGCCCTGCTGGTG Antisense: CCACTTCTCCTCCGAAGGTGC 157 bp AF233596 Biomedicines 2022,10, 265 8 of 38 2.12

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doi: 10.1371/journal.pone.0101473 159 WanY-XQiX-WLianY-YLiuZ-YWangHQiuY-Qet al

Alzheimers Disease Neuroimaging Initiative