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Lee SC, Ng SS, Oldenburg J, Chong PY, Rost S, Guo JY et al

Mice were treated by estradiol alone daily for 12 days (controls) or in combination with resveratrol daily for 20 days (controls)

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Dorph-Petersen KA, Lewis DA

The equivalent number of cells were seeded in a 12-well plate and treated with AFB 1 for 48 h

In organello assays with isolated damaged mitochondria as well as cell-based assays showed that PRT062607 and related compounds also inhibit human PINK1 and reduce its ability to phosphorylate Ub