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In a rat model, Mel inverted the decrease in the osteogenic differentiation ability of bone marrow MSCs, a condition usually associated with osteoporosis

Functioning as a central energy sensor, AMPK is a pivotal regulator of mitochondrial homeostasis, governing processes from mitochondrial generation to clearance via mitophagy

doi: 10.1208/s12248-021-00642-5 153 DeshaiesRJ

For instance, one clinical trial has used it as monotherapy or combined with cisplatin in lung and colon cancer patients with recurrent malignancies (NCT02433626)

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