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Within the pulmonary milieu, ozone interaction with unsaturated fatty acids can yield lipid ozonation products, engendering lipid peroxidation, perturbed membrane permeability, and subsequent activation of inflammatory mediators [84]

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This acidic condition can destabilise copper peptides, possibly breaking down their formulation, making both ingredients less or ineffective

Recently, several lines of evidence indicated that the HSPs can interact not only with misfolded proteins to prevent unfolded protein response (UPR) but also with native proteins to modulate several normal cellular functions ( hsp27 exhibited protective effects against 6-OHDA-induced toxicity by inhibiting cytochrome C release, caspase activation, thereby apoptosis ( sod-3 and HSP27 homologs by HLEA-P1 may enhance anti-oxidative and anti-apoptotic capacities, rendering the 6-OHDA less toxic