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Through activation of downstream Src homology 2 domain-containing transforming protein/FGF receptor substrate 2 (Shc/FRS-2) and phospholipase C- (PLC)/cAMP response element-binding protein signaling pathway, BDNF inhibits intracellular Cl - efflux and regulates ionic plasticity (165)

Interestingly, in human HCC with poorer prognosis (HCCP), higher MAT1A:MAT2A switch, CpG methylation, and histone H4 acetylation were found in human HCC with a better prognosis (HCCB) [33]