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Yu HJ, Zhang F, Yan PY, Zhang SS, Lou YM, Geng Z, et al

Glucagon receptor activation increases hepatic glucose production (relevant for energy balance), boosts basal metabolic rate (thermogenesis), and promotes lipolysis (fat breakdown)

Genes Dev 2015;29:19811991

They can assess whether the symptoms are genuinely related to the supplement, investigate alternative causes, and determine the most appropriate management strategy