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After 1 year, four of ten patients with positive SPT converted to negative, and six of nine patients with shrimp-specific IgE became negative

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Similarly a general mechanism of adaptive immune-evasion in EBV-associated malignancies is the overexpression of immune checkpoint proteins (e.g., PD-L1, IDO-1, CTLA-4, LAG-3, TIM-3, and VISTA), thus making them susceptible to treatment with immune checkpoint blocking immunotherapy (247)

The corresponding bulk material, however, showed significantly lower activity (0.590.01 M min -1 g -1 FW) which was comparable to the control

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