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95% CI, 0.520.90), despite significant heterogeneity among studies ( I 2 = 88%)

5% in blood Sporadic Myopathy Mechanism Reduced Assembly of COX enzyme Reduced Anchoring of COX II in mitochondrial membrane G7970T mutation (E129X) Myopathy Many COX- fibers Severe reduction in COX activity (10% to 20% residual) Lipid in type I fibers Fiber size: Mild variation Cataracts Hearing loss: Sensory-neural Ataxia Cardiac arrhythmia Depression Short stature Lactic acidosis G8009A: Somatic mutation found in colorectal cancer Biochemistry Lactate: Mildly increased in serum or CSF Oxidative enzymes: Selective reduction in COX activity Muscle pathology COX deficiency in 97% of muscle fibers: All COX subunits reduced Mitochondrial proliferation: Increased SDH stain, mild to moderate Myopathy, Deafness & CNS disorders 41 Mitochondrial tRNA Ser(UCN) (MTTS1)

demonstrated that senescent BV2 cells express higher levels of CD38, and the reduction in CD38 expression can effectively improve energy metabolism disorder, reduce proinflammatory cytokines, and ameliorate cognitive impairment [63]

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Low levels of insulin-like growth-factor-binding protein-1 (IGFBP-1) are prospectively associated with the incidence of type 2 diabetes and impaired glucose tolerance (IGT): the Sderkra Cardiovascular Risk Factor Study