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For example, cystic fibrosis patients suffer from severe gram-negative bacterial infections and are commonly prescribed the aminoglycoside antibiotics amikacin or tobramycin, despite as high as a 14% incidence of hearing loss (Cheng et al., 2007

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While direct receptor binding affinity remains an area of ongoing investigation, experimental evidence indicates that AOD 9604 enhances 3-adrenergic receptor expression and signaling capacity in adipose tissue models

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