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As shown in Figure 3, persistent hyperglycemia in T2DM triggers neurotoxic processes, including oxidative stress, the formation of advanced glycation end-products (AGEs), and chronic inflammation

Kapoor B, Kapoor D, Gautam S, Singh R, Bhardwaj S (2021) Dietary Polyunsaturated Fatty Acids (PUFAs): Uses and Potential Health Benefits

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Upon entering systemic circulation and reaching bone tissue, 5-HT attaches to the 5-HTR1B receptor on osteoblasts, which inhibits cAMP response element-binding protein (CREB) activity and cyclin expression, thereby suppressing osteoblast proliferation and differentiation and ultimately hindering bone formation (256)

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