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[DOI] [PubMed] [Google Scholar] 183.Munoz AM

Basu, S., Michalsson, K., Olofsson, H., Johansson, S

Wu et a., 2014[44]

Physiological Hyperpigmentation In physiological hyperpigmentation, deep tan, brown, dark-brown, or even black pigmentation occurs as symmetrical, flat, smooth-surfaced, asymptomatic darkening of the anogenital skin

The proteome alterations showed that curcumin suppresses Foxp3 expression while enhancing type II interferon production, skewing T cell differentiation toward Th1 phenotype and counteracting tumor immune evasion (29)

However, users must be aware of potential side effects, such as water retention or site-specific irritation, which are typical with potent secretagogues