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Downstream saturation / spare receptor full physiological response often achieved well below full occupancy because the cells downstream signaling pathway has its own ceiling

These changes may lead to sensations of dizziness or episodes of fainting if not adequately observed

[43:16] Andrew Huberman All the animal data come from one group

Because the patient is either not producing Intrinsic Factor or is destroying the Intrinsic Factor that has been produced the B12 cannot be absorbed from food