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1 This observation suggests that use of a low serum vitamin B 12 level as the sole means of diagnosis may miss up to one half of patients with actual tissue B 12 deficiency

Vasoactive intestinal peptide (VIP), a neurotransmitter of 28 amino acids found in the central and enteric nervous systems, plays a crucial role in regulating the balance between Th1 and Th2 balance

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2 Metformin-like compounds occur naturally in the plant Galega officinalis , and whilst it was used in medieval Europe to treat a variety of conditions, the plant is highly toxic with a potential to induce hypotension

While B12 is found naturally in animal-based foods like meat, fish, and dairy, certain groups are at a higher risk of deficiency: Vegetarians and Vegans: Plant-based diets lack adequate B12, as its primary sources are animal products