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Subsequently, this impairs IDH1-dependent reductive carboxylation, a tumor cell requirement limited to 3D growth, inducing a decrease in intramitochondrial NADPH, an increase in ROS, and finally mitochondrial supercomplexes assembly disruption, which ultimately impairs cell transformation and tumorigenesis

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doi: 10.2147/OTT.S164982 127 JiangKYaoGHuLYanYLiuJShiJet al