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Major drug Interactions: Not a substrate and does not affect CYP 450 isoenzymes Clopidogrel : oseltamivir is a prodrug activated by carboxylesterase, which is inhibited by clopidogrel, resulting in decreased levels of the active metabolite Probenecid : reduces the renal excretion of the active metabolite of oseltamivir Resistance: Influenza A & B resistance in ~5% of children Note: The antiviral resistance of a strain of influenza A (H1N1) to oseltamivir in 2008-09 was reported to be over 98%, however over 99% of pandemic influenzae A (H1N1) during the following 2009 pandemic were sensitive (Bartlett et al, 2010) - highlighting the importance of continuous surveillance programs, such as that maintained by the CDC

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PNS inhibited the apoptotic response of the intestinal epithelium by increasing the expression of Bcl-2 and Bcl-3 and significantly downregulating the expression levels of caspase-3 and Bax (Lu et al., 2020)

Wu X, Obata T, Khan Q, Highshaw RA, De Vere White R, Sweeney C

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