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The anxiolytic mechanism works through allosteric modulation of GABAA receptors

Cell 179:312339

As biofilms can increase the antibiotic resistance of bacteria up to 1,000-fold (Hiby et al., 2010), therefore the dissolution or prevention of these biofilms is an important part of the host antimicrobial defense and presents a challenge to both the host immune system and also the therapeutic development

For example, a large phase 3 study in sepsis did not show a clear reduction in short-term mortality

Climate considerations for Canadian users include storage challenges