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Through its deacetylase activity, the NAD + -dependent deacetylase sirtuin-1 (SIRT1) meticulously regulates a variety of substrates, such as histone and non-histone proteins, thereby producing significant effects on metabolic homeostasis, apoptosis regulation, inflammatory responses, attenuation of oxidative stress, and even the aging process (Tanno et al., 2007

doi: 10.1038/nature07039

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Hybridization would allow for a critical understanding of such tools, their scope and their conventional application, strengthening the planners role in what seems to have become a highly contested field of knowledge and practice, resulting in the partial marginality of such figure (Bonfantini, 2023)