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Animals and husbandry Male Sprague-Dawley rats (weighing approximately 180 g, 6 weeks old) were used

The standard treatment involves intramuscular cyanocobalamin (1 mg weekly for four weeks, then monthly for life) to prevent the recurrence of hematologic and neurological issues [21]

Although interventions such as carnosine (Abraham et al., 2021), folinic acid (Frye et al., 2018

78 (Suppl 1): 1419

Therefore, it is possible that the increased mTORC1 activation measured in FoB upon Gclc deletion can be a consequence of ROS accumulation and activation of the PI3K/AKT axis

On the other hand, excessive activation of the ERS-pyroptosis axis may exacerbate tumor-associated inflammation and immune suppression