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Boosting energy supplies produces excess free radicals from increased oxidative phosphorylation [14] which may not be neutralized if the cells have been operating in a low redox capacity with low activation of Antioxidant Response Elements (ARE) genes

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Intervention of diet is also one of the effective ways to improve NAFLD

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Hence, some drug development focuses on peripherally restricted KOR agonists to retain analgesic efficacy with a more favorable adverse effect [61]