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For example, combinations of redox-active drugs and metal ions, such as copper or silver, can promote thiol oxidation

however, the efficacy of SAM treatment needs further exploration in randomized prospective clinical trials

Research should be limited to in vitro studies and approved preclinical laboratory models

10.1136/bmjopen-2012-000990 114 JrgensenN.VierulaM.JacobsenR.PukkalaE.PerheentupaA.VirtanenH.et al (2011)

These signals are also relevant to the subsequent activation of homeostatic mechanisms that control the immune response in pro- or anti-inflammatory reactions, a feature that allows modulation by therapeutic treatments

Recognizing when symptoms indicate a need for a dosage adjustment prevents unnecessary discomfort