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In agreement, the early expression of SAG13 and SAG15 was also evident in vtc1 mutants (Barth et al., 2013b)

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Experimental findings further revealed that increased expression of fructose-metabolizing enzymes and fructose exposure in cardiomyocytes promoted glycolytic activity and lipid accumulation, strongly suggesting a direct role of the polyol pathway in diabetic cardiac dysfunction [24]

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It was shown to inhibit cytochrome c oxidase, leading to cell death through ATP depletion (Figure 1)

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