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Extended bioavailability compared to native IGF-1 due to reduced binding protein interaction [2]

Animal studies have shown some teratogenic potentialis, so its not recommended during the first trimester of pregnancy

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10.1007/s12325-022-02053-0 3 BattelinoT.DanneT.BergenstalR

UW228 shows partial sensitivity to SMO inhibitors and transient suppression of GLI1, with resistance mechanisms involving SUFU downregulation or GLI2 amplification

1986), and in the case of antiandrogen drugs, the flutamide nitro group is reduced to the nitroso group (in the presence of cyclodextrins) or substituted with the phenol group (in water) (Sortino et al