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Sudhakaran G, Prathap P, Guru A et al (2022) Reverse Pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating the levels of inflammatory cytokines in zebrafish larval model

The results of this study showed that PDI plays a pivotal role in mediating BSO-induced ferroptosis in HT22 cells through its ability to catalyze NOS dimerization, which is followed by cellular accumulation of NO, ROS and lipid peroxides, and ultimately, oxidative cell death

Cell death can induce the release of DAMPs, PAMPs, and alarmins recognized by immune receptors and, finally, aggravate ferroptosis and inflammation (118)

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Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity

Zinc monotherapy increases serum brain-derived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: a double-blind, randomized, placebo-controlled trial