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Dose chart for 30mg vials With 3ml water (10mg/ml concentration) : 30mg vial advantages : Lasts 3-12 weeks depending on dose Economical ($80-120 vs multiple 10mg vials) Flexible for any dose level Standard from most suppliers Supply needed (30mg vials) For complete 20-week protocol : Week 1-4 (2.5mg x 4 doses): 10mg total = 1/3 of vial Week 5-8 (5mg x 4 doses): 20mg total = 2/3 of vial First vial lasts 8 weeks Week 9-12 (7.5mg x 4 doses): 30mg total = 1 vial Week 13-16 (10mg x 4 doses): 40mg total = 1.33 vials Week 17-20 (12.5mg x 4 doses): 50mg total = 1.67 vials Total : 4-5 vials for complete 20-week protocol Cost : $320-600 for complete protocol (at $80-120 per 30mg vial) Most economical option for full protocol

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Financial support and sponsorship This work was supported by grants from the National Science Foundation ( IOS-1557341 (HFN, MCR) and DMS-2038056 (AC)

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Unraveling the molecular signatures of Lupus-Associated osteoarthritis: A comprehensive review of novel biomarker strategies