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doi: 10.1038/ncomms6712

10.1124/mol.117.109926 30 GouH.ChenX.ZhuX.LiL.HouL.ZhouY.et al (2022)

All analyses were conducted in R version 4.4.3 (RStudio)

Other causes of PPHN include constriction of the fetal ductus arteriosus in utero which can occur after exposure of fetus to non-steroidal anti-inflammatory drugs (NSAIDS) or selective serotonin reuptake inhibitors (SSRI) during late gestation (1517)

Importantly, as proteasome activation by pharmacological agents has been proposed as a promising approach to delay aging and the development of age-related diseases (Chondrogianni et al., 2015), dogs may provide an appropriate large animal model for pre-clinical testing of these interventions, especially in the case of brain pathologies

Our advanced high-performance liquid chromatography testing protocols verify not only the concentration of active compounds but also confirm the absence of harmful contaminants and degradation products