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Oral DMTs: An alternative to injectable therapies In 2010, fingolimod (Gilenya , Novartis, Switzerland) was the first oral MS DMT approved by the FDA, with teriflunomide (Aubagio , Genzyme, France) following in 2012 and cladribine (Mavenclad , Merck, Germany) in 2017 approved by the EMA

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FIGURE 3 The H 2 S-releasing capacity of compounds is closely associated with their molecular structures

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