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Senile plaques (extracellular depositions) and neuronal tangles (intracellular accumulation of misphosphorylated tau protein), are the main histopathological hallmarks of the AD, critical for post-mortem diagnosis

During embryonic development, the size of the NPCs pool is determined by the proliferative capacity, intricately coordinated with the apoptosis rate

Tryptophan-kynurenine metabolism Tryptophan is an essential amino acid with multiple metabolic fates and crucial in cell danger response, being again gut microbiota a modulator of its metabolic pathways [208]