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Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

doi: 10.1152/ajprenal.1982.242.4.F406

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Interestingly, 72 h of OSKM induction caused a decrease in the amount of H3K36me3 across gene bodies relative to all reads, which was prevented by vitamin B 12 supplementation (Fig

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