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& Sharma, R

The tetrasulfide bonds within VGd@ICG-FA are responsive to GSH

University of Minnesota Hyun Kim, Mandi DeGrote

ECM38 encodes the glutathione-degrading enzyme -glutamyl transpeptidase while the DUG3 product is part of the Dug2p/Dug3p complex involved in cytoplasmic glutathione degradation in yeasts and fungi (24)

However, when resistance does occur, such as in Candida albicans or Aspergillus , it is typically associated with mutations in the ergosterol biosynthesis pathway, particularly in genes such as ERG2 , ERG3 , ERG5 and ERG11 ( Jensen et al., 2015)