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For urgent concerns such as severe abdominal pain, inability to pass stools or wind for several days, or signs of rectal bleeding with dizziness or faintingcontact NHS 111 or attend your local A&E department

In addition, our group and other researchers have recently demonstrated that DFO could alleviate OA by inhibiting chondrocyte ferroptosis [23, 128]

This subsequently contributes to the intracellular accumulation of ferric ions, along with the generation of large amounts of ROS

TEM was performed as an imaging procedure using an electron microscope (JEM-100 CX, JEOL, Tokyo, Japan)

(1991) Biochemistry 30, 6124-6127]

Collectively, these studies provide a versatile natural-product toolbox that can be rationally combined for precision ferroptosis therapy