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Some researchers report stable results up to 45 or 60 days, but 28 days is the window within which potency is most reliably maintained

Avrutsky et al., 2023)

Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)