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Philos Trans R Soc B Biol Sci 373(1748):20170069

Trends Endocrinol Metabolism

Res Mol Med

Lipid Res 85 , 101139 (2022)

Loss of myelin impairs nerve signal transmission, causing the progressive neurological symptoms characteristic of MS

Keywords: autonomic nervous system, chronic pain, fatigue, near-infrared spectroscopy, fibromyalgia, magnetic resonance imaging, microcirculation, mitochondrial dysfunction, muscle oxygen saturation, physiological mechanisms, therapeutic strategies Introduction Fibromyalgia, recognized as a chronic syndrome distinguished by widespread musculoskeletal pain and significant fatigue, presents a complex clinical landscape that poses challenges to both patients and healthcare practitioners.1 The condition ensnares individuals within a labyrinth of diverse symptoms, encompassing sleep disturbances, autonomic dysfunctions, cognitive deficits, an exaggerated response to pain and other stimuli, somatic complaints, and concurrent psychiatric disorders.2,3 Among its hallmark features, widespread inflammation is prominently acknowledged in the literature as a pivotal factor exacerbating pain.4 This relationship establishes a pernicious cycle wherein increased pain discourages physical activity, leading to heightened sedentary behavior