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Health 15 , 100838 (2021)

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[DOI] [PubMed] [Google Scholar] 49.Kato Y., Wu X., Naito M., Nomura H., Kitamoto N., Osawa T

Although it is well characterized that pathological -synuclein propagates in a prion-like fashion from the stomach and duodenum to the brain via the vagus (Van Den Berge et al., 2019), how the appendix facilitates the pathological spread is unanswered since the evidence shows increased levels of -synuclein with significant enrichment within the axonal varicosities of the mucosal plexus ( via DNA methylation of genes related to the production of autophagic protein and lysosomal degradation pathways (Figure 3A) ( in vivo , thereby increasing the risk of developing PD (Wang et al., 2018)

The patellar tendon works with the muscles in the Fibromyalgia: The Disease That Hurts According to the Fibromyalgia Association (AFIBROM), this condition affects 2.45% of the worlds population and more than 90% are women, between 30 and 55 years of age